Issue 8, 2008

Catalytic asymmetric aldol reactions in aqueous media

Abstract

Nature has perfected the stereospecific aldol reaction by using aldolase enzymes. While virtually all the biochemical aldol reactions use unmodified donor and acceptor carbonyls and take place under catalytic control in an aqueous environment, the chemical domain of the aldol addition has mostly relied on prior transformation of carbonyl substrates, and the whole process traditionally is carried out in anhydrous solvents. The area of aqua-asymmetric aldol reactions has received much attention recently in light of the perception both of its green chemistry advantages and its analogy to eon-perfected enzyme catalysis. Both chiral metal complexes and small chiral organic molecules have been recently reported to catalyze aldol reactions with relatively high chemical and stereochemical efficiency. This tutorial review describes recent developments in this area.

Graphical abstract: Catalytic asymmetric aldol reactions in aqueous media

Article information

Article type
Tutorial Review
Submitted
21 Apr 2008
First published
09 Jun 2008

Chem. Soc. Rev., 2008,37, 1502-1511

Catalytic asymmetric aldol reactions in aqueous media

J. Mlynarski and J. Paradowska, Chem. Soc. Rev., 2008, 37, 1502 DOI: 10.1039/B710577K

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements