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Issue 9, 2006
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Glycolipids for natural killer T cells

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Abstract

Natural killer T cells (NKT cells) play a central role in regulating immune responses influencing conditions ranging from autoimmune to infectious diseases. NKT cell responses are induced by recognition of glycolipid antigens presented by CD1d, an antigen presentation protein. In the last 10 years great strides have been made in understanding the types of glycolipids recognized by NKT cells. These advances have included determination of the lipid and carbohydrate recognition requirements for stimulation and identification of “natural” antigens for these cells.

Graphical abstract: Glycolipids for natural killer T cells

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Publication details

The article was received on 18 Apr 2006 and first published on 09 Jun 2006


Article type: Tutorial Review
DOI: 10.1039/B510638A
Citation: Chem. Soc. Rev., 2006,35, 771-779
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    Glycolipids for natural killer T cells

    P. B. Savage, L. Teyton and A. Bendelac, Chem. Soc. Rev., 2006, 35, 771
    DOI: 10.1039/B510638A

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