Jump to main content
Jump to site search

Issue 7, 2004
Previous Article Next Article

The synthesis of peptides and proteins containing non-natural amino acids

Author affiliations

Abstract

Methods for the incorporation of non-natural amino acids into proteins have advanced significantly over recent years and in this tutorial review we aim to give a general overview of the area. These techniques offer the possibility of modulating the structures and functions of proteins and thus permit the generation of novel designed systems for both biocatalytic and mechanistic studies. Four complementary approaches are discussed in detail along with examples of their application. The advantages and disadvantages of each technique are also discussed.

Graphical abstract: The synthesis of peptides and proteins containing non-natural amino acids

Back to tab navigation

Publication details

The article was received on 16 Feb 2004 and first published on 13 Aug 2004


Article type: Tutorial Review
DOI: 10.1039/B312953P
Citation: Chem. Soc. Rev., 2004,33, 422-430
  •   Request permissions

    The synthesis of peptides and proteins containing non-natural amino acids

    D. R. W. Hodgson and J. M. Sanderson, Chem. Soc. Rev., 2004, 33, 422
    DOI: 10.1039/B312953P

Search articles by author

Spotlight

Advertisements