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Issue 7, 2004
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Extracellular proteases as targets for treatment of cancer metastases

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Abstract

Metastasis, the dissemination of tumor cells to distant organs, is often associated with fatal outcome in cancer patients. Formation of metastasis requires degradation of extracellular matrices and several families of proteases have been implicated in this process, including matrix metalloproteinases (MMPs), serine and cysteine proteases. Inhibition of these enzymes in animal models of metastasis has shown impressive therapeutic effects. This report discusses the various approaches used for enzyme inhibition and describes new developments in drug design for inhibition of proteases in metastatic disease.

Graphical abstract: Extracellular proteases as targets for treatment of cancer metastases

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Publication details

The article was received on 07 Jan 2004 and first published on 13 Aug 2004


Article type: Tutorial Review
DOI: 10.1039/B209224G
Citation: Chem. Soc. Rev., 2004,33, 401-409
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    Extracellular proteases as targets for treatment of cancer metastases

    M. Lee, R. Fridman and S. Mobashery, Chem. Soc. Rev., 2004, 33, 401
    DOI: 10.1039/B209224G

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