Jump to main content
Jump to site search

Issue 1, 1997
Previous Article Next Article

Towards a general triple helix mediated DNA recognition scheme

Abstract

This review describes new perspectives offered by the synthesis of non-natural nucleosides to overcome current limitations and extend the triplex-mediated DNA recognition scheme to any sequence. Alternate strand purine binding, direct pyrimidine recognition, and binding to the whole base-pair are described. The review highlights structural requirements to the design of modified nucleosides, as well as perturbing events such as tautomeric ambiguity and intercalation for the extended heterocyclic bases.

Back to tab navigation

Article type: Review Article
DOI: 10.1039/CS9972600063
Citation: Chem. Soc. Rev., 1997,26, 63-71
  •   Request permissions

    Towards a general triple helix mediated DNA recognition scheme

    S. O. Doronina and J. Behr, Chem. Soc. Rev., 1997, 26, 63
    DOI: 10.1039/CS9972600063

Search articles by author

Spotlight

Advertisements