Issue 24, 2017

On the mechanism of mechanochemical molecular encapsulation in peptidic capsules

Abstract

Molecular encapsulation of C60 inside a hydrogen-bond-sealed semi-flexible peptidic capsule is hindered in solution, yet it proceeds effectively after mechanical milling of a solid sample. We show that the molecular mechanism involves the generation of non-covalently disordered forms that are active in guest uptake. We also show that the solvent-free mechanochemical covalent synthesis of capsules directly results in obtaining disordered, active forms.

Graphical abstract: On the mechanism of mechanochemical molecular encapsulation in peptidic capsules

Supplementary files

Article information

Article type
Communication
Submitted
20 Apr 2017
Accepted
26 May 2017
First published
09 Jun 2017
This article is Open Access
Creative Commons BY license

Phys. Chem. Chem. Phys., 2017,19, 15676-15680

On the mechanism of mechanochemical molecular encapsulation in peptidic capsules

M. P. Szymański, H. Jędrzejewska, M. Wierzbicki and A. Szumna, Phys. Chem. Chem. Phys., 2017, 19, 15676 DOI: 10.1039/C7CP02603J

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