Issue 34, 2016

Study of the binding mechanism between aptamer GO18-T-d and gonyautoxin 1/4 by molecular simulation

Abstract

GTX1/4 can induce the formation of an antiparallel G-quadruplex structure in aptamer GO18-T-d and combine steadily in the groove at the top of the G-quadruplex structure. The complex structures and special induced fit mechanism between aptamer and small molecules provide a reference for aptamer development in molecular diagnostics and therapeutic application.

Graphical abstract: Study of the binding mechanism between aptamer GO18-T-d and gonyautoxin 1/4 by molecular simulation

Supplementary files

Article information

Article type
Communication
Submitted
03 Feb 2016
Accepted
09 Apr 2016
First published
13 Apr 2016

Phys. Chem. Chem. Phys., 2016,18, 23458-23461

Study of the binding mechanism between aptamer GO18-T-d and gonyautoxin 1/4 by molecular simulation

S. Gao, B. Hu, X. Zheng, D. Liu, M. Sun, J. Qin, H. Zhou, B. Jiao and L. Wang, Phys. Chem. Chem. Phys., 2016, 18, 23458 DOI: 10.1039/C6CP00777E

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