Issue 5, 2012

Atomic-level investigations on the amyloid-β dimerization process and its driving forces in water

Abstract

We report the spontaneous dimerization process of the full-length Aβ42 proteins in water by using unguided, fully atomistic, explicit-water molecular dynamics simulations. Based on the thermodynamic analysis, we demonstrate that Aβ42 dimerization in water occurs via a two-step nucleation–accommodation mechanism driven by water-induced force and by protein internal force, respectively.

Graphical abstract: Atomic-level investigations on the amyloid-β dimerization process and its driving forces in water

Supplementary files

Article information

Article type
Communication
Submitted
21 Oct 2011
Accepted
05 Dec 2011
First published
06 Dec 2011

Phys. Chem. Chem. Phys., 2012,14, 1573-1575

Atomic-level investigations on the amyloid-β dimerization process and its driving forces in water

S. Chong and S. Ham, Phys. Chem. Chem. Phys., 2012, 14, 1573 DOI: 10.1039/C2CP23326F

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