Issue 16, 2011

Magnetic field induced aggregation of nanoparticles for sensitive molecular detection

Abstract

A molecular detection method utilizing the magnetically induced aggregation of silver nanoparticle (NP)-embedded silica NPs for SERS activation is described. Here, silver embedded magnetic NPs (Ag-M-dots) composed of a magnetic core and silica shells, on whose surface silver NPs were formed, were used. Because the magnetic field induced aggregated Ag-M-dots exhibit a strong SERS signal compared to the dispersed Ag-M-dots, the system allows for the detection of adsorbed Raman label compound even at the 100 fM level. Adenine was tested as a model biocompound and its Raman spectrum could be observed at concentrations as low as 1 pM. The experimental results were supported by the theoretical calculations.

Graphical abstract: Magnetic field induced aggregation of nanoparticles for sensitive molecular detection

Supplementary files

Article information

Article type
Paper
Submitted
06 Oct 2010
Accepted
21 Dec 2010
First published
14 Jan 2011

Phys. Chem. Chem. Phys., 2011,13, 7298-7303

Magnetic field induced aggregation of nanoparticles for sensitive molecular detection

B. Jun, G. Kim, J. Baek, H. Kang, T. Kim, T. Hyeon, D. H. Jeong and Y. Lee, Phys. Chem. Chem. Phys., 2011, 13, 7298 DOI: 10.1039/C0CP02055A

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