Issue 8, 2011
From the journal:

Physical Chemistry Chemical Physics

Simple model for the growth behaviour of mixed lecithin–bile salt micelles†

Dilek Madenci,*a   Anniina Salonen,bc   Peter Schurtenberger,d   Jan Skov Pedersene  and  Stefan U. Egelhaaf*abf  

* Corresponding authors

a Condensed Matter Physics Laboratory, Heinrich-Heine-University, 40225 Düsseldorf, Germany
E-mail: dilek.madenci@uni-duesseldorf.de, stefan.egelhaaf@uni-duesseldorf.de
Fax: +49–211–81 14850
Tel: +49–211–81 14325

b SUPA, School of Physics and Astronomy, University of Edinburgh, Edinburgh EH9 3JZ, UK

c Laboratoire de Physique des Solides, UMR 8502, Université Paris Sud, 91405 Orsay cedex, France

d Division of Physical Chemistry, Center for Chemistry and Chemical Engineering, Lund University, 221 00 Lund, Sweden

e Department of Chemistry and iNANO Interdisciplinary Nanoscience Centre, Aarhus University, 8000 Aarhus, Denmark

f Institute Laue-Langevin, 38042 Grenoble, France

Abstract

Mixed lecithin–bile salt micelles are known to have a cylindrical or worm-like structure. We investigated their shape, length, flexibility and cross-sectional structure using small-angle neutron scattering (SANS). A broad range of sample compositions was studied varying both the total amphiphile concentration and the molar ratio of bile salt (sodium taurochenodeoxycholate, NaTCDC) to lecithin (egg yolk phosphatidylcholine, EYL). The length of the micelles was quantitatively linked to the micellar composition by introducing a simple model. The model takes into account the partitioning of lecithin and bile salt between the bulk, cylindrical parts and the end caps of the micelles. The model also sheds light on the organization of the micelles, both in their cylindrical regions and end caps.

Graphical abstract: Simple model for the growth behaviour of mixed lecithin–bile salt micelles

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Article information

DOI
https://doi.org/10.1039/C0CP01700K
Article type
Paper
Submitted
03 Sep 2010
Accepted
09 Nov 2010
First published
07 Dec 2010

Phys. Chem. Chem. Phys., 2011,13, 3171-3178

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Simple model for the growth behaviour of mixed lecithin–bile salt micelles

D. Madenci, A. Salonen, P. Schurtenberger, J. S. Pedersen and S. U. Egelhaaf, Phys. Chem. Chem. Phys., 2011, 13, 3171 DOI: 10.1039/C0CP01700K

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