Issue 22, 2010
From the journal:

Physical Chemistry Chemical Physics

Feasibility of in vivo15N MRS detection of hyperpolarized 15N labeled choline in rats

Cristina Cudalbu,*a   Arnaud Comment,abc   Fiodar Kurdzesau,bd   Ruud B. van Heeswijk,a   Kai Uffmann,a   Sami Jannin,b   Vladimir Denisov,e   Deniz Kirike  and  Rolf Gruetteracf  

* Corresponding authors

a Laboratory for Functional and Metabolic Imaging, Ecole Polytechnique Fédérale de Lausanne, EPFL-SB-IPMC-LIFMET, Office F1 602, Station 6, CH-1015 Lausanne, Switzerland
E-mail: cristina.cudalbu@epfl.ch
Fax: +41-21-693-7960
Tel: +41-21-693-0580

b Institute of Condensed Matter Physics, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland

c Department of Radiology, University of Lausanne, Switzerland

d Paul Scherrer Institute, Villigen, Switzerland

e Department of Experimental Medical Science, Brain Repair and Imaging in Neural Systems (BRAINS), Lund University, Lund, Sweden

f Department of Radiology, University of Geneva, Switzerland

Abstract

The increase of total choline in tumors has become an important biomarker in cancer diagnosis. Choline and choline metabolites can be measured in vivo and in vitro using multinuclear MRS. Recent in vivo13C MRS studies using labeled substrates enhanced via dynamic nuclear polarization demonstrated the tremendous potential of hyperpolarization for real-time metabolic studies. The present study demonstrates the feasibility of detecting hyperpolarized 15N labeled choline in vivo in a rat head at 9.4 T. We furthermore report the in vitro (172 ± 16 s) and in vivo (126 ± 15 s) longitudinal relaxation times. We conclude that with appropriate infusion protocols it is feasible to detect hyperpolarized 15N labeled choline in live animals.

Graphical abstract: Feasibility of in vivo15N MRS detection of hyperpolarized 15N labeled choline in rats

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Article information

DOI
https://doi.org/10.1039/C002309B
Article type
Paper
Submitted
02 Feb 2010
Accepted
23 Apr 2010
First published
12 May 2010

Phys. Chem. Chem. Phys., 2010,12, 5818-5823

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Feasibility of in vivo15N MRS detection of hyperpolarized 15N labeled choline in rats

C. Cudalbu, A. Comment, F. Kurdzesau, R. B. van Heeswijk, K. Uffmann, S. Jannin, V. Denisov, D. Kirik and R. Gruetter, Phys. Chem. Chem. Phys., 2010, 12, 5818 DOI: 10.1039/C002309B

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