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Issue 14, 2010
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Six conformers of neutral aspartic acid identified in the gas phase

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Abstract

The multiconformational landscape of the proteogenic amino acid aspartic acid, the simplest amino acid with two carboxylic groups, has been explored for the first time in the gas phase. Solid aspartic acid (m.p. > 300 °C) was vaporized by laser ablation and expanded in a supersonic jet where rotational spectra of various conformers were obtained by Fourier transform microwave spectroscopy. Six different conformers have been conclusively identified by their distinct rotational and 14N nuclear quadrupole coupling constants. The relative stability of the conformers rests on a delicate balance of the different intramolecular hydrogen bonds established between the two carboxylic groups and the amino group.

Graphical abstract: Six conformers of neutral aspartic acid identified in the gas phase

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Publication details

The article was received on 16 Dec 2009, accepted on 26 Feb 2010 and first published on 05 Mar 2010


Article type: Paper
DOI: 10.1039/B926520A
Citation: Phys. Chem. Chem. Phys., 2010,12, 3573-3578
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    Six conformers of neutral aspartic acid identified in the gas phase

    M. E. Sanz, J. C. López and J. L. Alonso, Phys. Chem. Chem. Phys., 2010, 12, 3573
    DOI: 10.1039/B926520A

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