Multiscale approaches for studying energy transduction in dynein
Abstract
Cytoplasmic dynein is an important motor that drives all minus-end directed movement along microtubules. Dynein is a complex motor whose processive motion is driven by ATP-hydrolysis. Dynein’s run length has been measured to be several millimetres with typical velocities in the order of a few nanometres per second. Therefore, the average time between steps is a fraction of a second. When this time scale is compared with typical time scales for protein side chain and backbone movements (∼10−9 s and ∼10−5 s, respectively), it becomes clear that a multi-timescale modelling approach is required to understand energy transduction in this
- This article is part of the themed collection: Physical chemistry of biomolecular motors and machines