Issue 19, 2002
From the journal:

Physical Chemistry Chemical Physics

Raman spectroscopic study of Ni2+–DNA interactions in aqueous systems

Janusz Stangret*a  and  Rodrigue Savoieb  

* Corresponding authors

a Department of Physical Chemistry, Technical University of Gdańsk, Gdańsk, Poland

b Department of Chemistry, Laval University, Québec, Québec, Canada

Abstract

The interactions of Ni2+ ion with calf thymus DNA has been studied in water at metal/DNA phosphate mole ratios ranging from 0.0125 to 6 using Raman spectroscopy. The weighted difference spectra method has been applied to analyze the data. It has been established that Ni2+ ion coordinates mainly at N7 centers of guanine (G) and adenine (A) of DNA at GG, AA and GA sequence places. At the same time the Ni2+ shows outer-sphere interaction, via water molecules, with phosphate groups of DNA.

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Article information

DOI
https://doi.org/10.1039/B202346F
Article type
Paper
Submitted
05 Mar 2002
Accepted
31 Jul 2002
First published
30 Aug 2002

Phys. Chem. Chem. Phys., 2002,4, 4770-4773

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Raman spectroscopic study of Ni2+–DNA interactions in aqueous systems

J. Stangret and R. Savoie, Phys. Chem. Chem. Phys., 2002, 4, 4770 DOI: 10.1039/B202346F

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