Issue 33, 2013
From the journal:

CrystEngComm

Simultaneously enhancing the solubility and permeability of acyclovir by crystal engineering approach†

Yan Yan,a   Jia-Mei Chen*a  and  Tong-Bu Lu*a  

* Corresponding authors

a MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, State Key Laboratory of Optoelectronic Materials and Technologies, School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275, China
E-mail: lutongbu@mail.sysu.edu.cn
Fax: +86-20-84112921

Abstract

Three acyclovir complexes including one salt with maleic acid, and two cocrystals with fumaric acid and glutaric acid, were prepared. The results of powder dissolution and in vitro skin permeation experiments revealed that both solubility and permeability of acyclovir were enhanced after the formation of cocrystals.

Graphical abstract: Simultaneously enhancing the solubility and permeability of acyclovir by crystal engineering approach

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Article information

DOI
https://doi.org/10.1039/C3CE41017J
Article type
Communication
Submitted
05 Jun 2013
Accepted
19 Jun 2013
First published
16 Jul 2013

CrystEngComm, 2013,15, 6457-6460

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Simultaneously enhancing the solubility and permeability of acyclovir by crystal engineering approach

Y. Yan, J. Chen and T. Lu, CrystEngComm, 2013, 15, 6457 DOI: 10.1039/C3CE41017J

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