Issue 7, 2012

The role of mechanochemistry and supramolecular design in the development of pharmaceutical materials

Abstract

The development of modern pharmaceutical solid forms, including solvates, polymorphs, salts or cocrystals, is related to the design and control of molecular self-assembly processes. Mechanochemistry has emerged as an excellent experimental approach to rapidly and efficiently screen for and synthesise such pharmaceutical materials. This is particularly the case for pharmaceutical cocrystals which are of considerable interest in the area of modern solid-state pharmaceutical materials science. Mechanochemistry has also been demonstrated as a successful technique to screen and synthesise metal–organic pharmaceutical derivatives (herein addressed as metallopharmaceuticals) as well as metallodrugs. The quantitative yields and high crystallinity of products obtained via mechanochemical synthesis enables the efficient coupling of solvent-free screening and structure determination from powder X-ray diffraction data to provide rapid advances in systematic studies and the structural understanding of pharmaceutical forms based on hydrogen bonding interactions or coordination bonds. In this review, we describe how mechanochemical methods have improved the development of new solid forms and their structural understanding, as well as the development of supramolecular strategies for the crystal engineering of pharmaceutical solid forms.

Graphical abstract: The role of mechanochemistry and supramolecular design in the development of pharmaceutical materials

Article information

Article type
Highlight
Submitted
24 Nov 2011
Accepted
25 Jan 2012
First published
03 Feb 2012

CrystEngComm, 2012,14, 2350-2362

The role of mechanochemistry and supramolecular design in the development of pharmaceutical materials

A. Delori, T. Friščić and W. Jones, CrystEngComm, 2012, 14, 2350 DOI: 10.1039/C2CE06582G

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements