Issue 7, 2012

Blonanserin HCl salt and its monohydrate

Abstract

X-Ray crystal structure of the hydrochloride salt of an antipsychotic drug blonanserin (BLN) and characterization of a high temperature polymorph are reported. The crystal structure of BLN HCl monohydrate was determined. All new solid-state forms are characterized by X-ray diffraction, thermal microscopy, ss-NMR, and FT-IR spectroscopy. BLN HCl transformed to its monohydrate form during solubility measurement. The solubility of BLN and BLN HCl monohydrate in 60% EtOHwater is 1.6 g L−1 and 119.2 g L−1 respectively.

Graphical abstract: Blonanserin HCl salt and its monohydrate

Supplementary files

Article information

Article type
Communication
Submitted
14 Oct 2011
Accepted
01 Dec 2011
First published
16 Dec 2011

CrystEngComm, 2012,14, 2367-2372

Blonanserin HCl salt and its monohydrate

D. Maddileti, R. Thakuria, S. Cherukuvada and A. Nangia, CrystEngComm, 2012, 14, 2367 DOI: 10.1039/C2CE06367K

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