A novel bioaffinity material: the systhesis, biointeraction, and electrochemical behavior of InVO4 nanoribbons

Abstract

In this paper, indium vanadate (InVO₄) nanoribbons were obtained by a facile hydrothermal process and were confirmed to have an affinity for hemoglobin (Hb) for the first time: ultraviolet-visible absorption and photoluminescence spectroscopy indicated an interaction between InVO₄ and porphyrin, as well as the tryptophan (Trp) and tyrosine (Tyr) residues in Hb; and partial unfolding of the Hb α-helix was testified by circular dichroism spectra. Based on the interaction between InVO₄ and Hb, InVO₄ was employed to modify a glassy carbon electrode, which displayed excellent electrochemical sensitivity in detecting Hb. A linear relationship between the concentration of Hb and its reduction peak currents was obtained. The modified electrode exhibited high reproducibility and stability, which might find potential applications in biosensors.