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Issue 9, 2008
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Co-crystallisation at high pressure—an additional tool for the preparation and study of co-crystals

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Abstract

Crystallisation of paracetamol and piperazine from ethanol at a pressure of 0.57 GPa produced an ethanol solvate of a 2 : 1 co-crystal of paracetamol : piperazine. This contrasts with crystallisation from ethanol at ambient pressure for which only an unsolvated 2 : 1 co-crystal of paracetamol : piperazine has been obtained. The hydrogen bonding arrangements of the two compounds are very different and a striking feature of the solvate is the presence of an unusually short hydrogen bond between the phenolic and amine groups.

Graphical abstract: Co-crystallisation at high pressure—an additional tool for the preparation and study of co-crystals

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Publication details

The article was received on 02 Apr 2008, accepted on 14 May 2008 and first published on 04 Jun 2008


Article type: Communication
DOI: 10.1039/B805591B
Citation: CrystEngComm, 2008,10, 1114-1116
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    Co-crystallisation at high pressure—an additional tool for the preparation and study of co-crystals

    I. D. H. Oswald and C. R. Pulham, CrystEngComm, 2008, 10, 1114
    DOI: 10.1039/B805591B

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