Issue 49, 2018

Ytterbium and silver co-catalyzed synthesis of pyrrole-fused bicyclic skeletons from enynones and isocyanides

Abstract

An unusual cascade reaction of isocyanide and enynone using Yb/Ag cooperative catalysis as a key step has been disclosed. The present strategy enables the double isocyanide insertion and subsequent 5-endo-dig cyclization, thus providing a quick access to structurally complex pyrrole-fused heterocycles.

Graphical abstract: Ytterbium and silver co-catalyzed synthesis of pyrrole-fused bicyclic skeletons from enynones and isocyanides

Supplementary files

Article information

Article type
Communication
Submitted
29 Apr 2018
Accepted
30 May 2018
First published
30 May 2018

Chem. Commun., 2018,54, 6412-6415

Ytterbium and silver co-catalyzed synthesis of pyrrole-fused bicyclic skeletons from enynones and isocyanides

F. Li, P. Hu, M. Sun, C. Li, X. Jia and J. Li, Chem. Commun., 2018, 54, 6412 DOI: 10.1039/C8CC03475C

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