Hydration effects on Leu's polyproline II population in AcLXPNH2

Yan Zhang; Yanjun Zhou; Liu He; Yu Fu; Wenwen Zhang; Jingjing Hu; Zhengshuang Shi

doi:10.1039/C8CC02402B

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Hydration effects on Leu's polyproline II population in AcLXPNH₂†

Yan Zhang,‡^a Yanjun Zhou,‡^a Liu He,‡^b Yu Fu,^a Wenwen Zhang,^a Jingjing Hu^a and Zhengshuang Shi

*^a

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* Corresponding authors

^a School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, 1037 Luoyu Road, Wuhan 430074, P. R. China
E-mail: kevinshi@gmail.com

^b Department of Medicinal Chemistry, Virginia Commonwealth University, Richmond, Virginia 23298, USA

Abstract

Hydration is important in many fundamental processes. To investigate hydration effects on peptide conformations, we examined neighboring-residue and side-chain blocking effects in AcLXPNH₂. A correlation between two effects suggests that hydration stabilizes PII more than β-structures. Our results are important for understanding the hydration effects on peptide conformations and hydration-forces in general.

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Article information

DOI: https://doi.org/10.1039/C8CC02402B
Article type: Communication
Submitted: 26 Mar 2018
Accepted: 10 May 2018
First published: 10 May 2018

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Chem. Commun., 2018,54, 5764-5767

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Hydration effects on Leu's polyproline II population in AcLXPNH₂

Y. Zhang, Y. Zhou, L. He, Y. Fu, W. Zhang, J. Hu and Z. Shi, Chem. Commun., 2018, 54, 5764 DOI: 10.1039/C8CC02402B

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