Issue 40, 2018

Highly enantioselective synthesis of trifluoromethyl cyclopropanes by using Ru(ii)–Pheox catalysts

Abstract

An asymmetric synthesis of various trifluoromethyl cyclopropanes from olefins, such as vinyl ferrocene, vinyl ethers, vinyl amines, vinyl carbamates and dienes, was achieved by using Ru(II)–Pheox catalysts. This catalytic system can function at a low catalyst loading (3 mol%) compared with those reported previously, and the desired cyclopropane products are obtained in high yields with excellent diastereoselectivity (up to >99 : 1) and enantioselectivity (up to 97% ee).

Graphical abstract: Highly enantioselective synthesis of trifluoromethyl cyclopropanes by using Ru(ii)–Pheox catalysts

Supplementary files

Article information

Article type
Communication
Submitted
22 Mar 2018
Accepted
24 Apr 2018
First published
30 Apr 2018

Chem. Commun., 2018,54, 5110-5113

Highly enantioselective synthesis of trifluoromethyl cyclopropanes by using Ru(II)–Pheox catalysts

M. Kotozaki, S. Chanthamath, T. Fujii, K. Shibatomi and S. Iwasa, Chem. Commun., 2018, 54, 5110 DOI: 10.1039/C8CC02286K

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