Issue 34, 2018

[18F]fluoro-benziodoxole: a no-carrier-added electrophilic fluorinating reagent. Rapid, simple radiosynthesis, purification and application for fluorine-18 labelling

Abstract

Operationally simple radiosynthesis and purification of [18F]fluoro-benziodoxole was developed starting from a cyclotron produced [18F]F precursor, [18F]TBAF, and tosyl-benziodoxole. The synthetic utility of [18F]fluoro-benziodoxole was demonstrated by electrophilic fluorocyclization of o-styrilamides proceeding with high RCC (typically 50–90%) and high molar activity (up to 396 GBq μmol−1).

Graphical abstract: [18F]fluoro-benziodoxole: a no-carrier-added electrophilic fluorinating reagent. Rapid, simple radiosynthesis, purification and application for fluorine-18 labelling

Supplementary files

Article information

Article type
Communication
Submitted
22 Jan 2018
Accepted
03 Apr 2018
First published
03 Apr 2018
This article is Open Access
Creative Commons BY-NC license

Chem. Commun., 2018,54, 4286-4289

[18F]fluoro-benziodoxole: a no-carrier-added electrophilic fluorinating reagent. Rapid, simple radiosynthesis, purification and application for fluorine-18 labelling

M. A. Cortés González, P. Nordeman, A. Bermejo Gómez, D. N. Meyer, G. Antoni, M. Schou and K. J. Szabó, Chem. Commun., 2018, 54, 4286 DOI: 10.1039/C8CC00526E

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