Copper-catalyzed synthesis of α-amino nitriles through methyl transfer from DMF to aromatic amines

Abstract

A copper-catalyzed activation of C(sp³)–H bonds of DMF at room temperature was developed, which results in methyl transfer to aromatic amines for efficient synthesis of exceedingly valuable α-amino nitriles. This process features excellent functional group tolerance, a broad substrate scope, and high activity under ambient conditions.