Red fluorescent probes for real-time imaging of the cell cycle by dynamic monitoring of the nucleolus and chromosome

Kang-Nan Wang; Xi-Juan Chao; Bing Liu; Dan-Jie Zhou; Liang He; Xiao-Hui Zheng; Qian Cao; Cai-Ping Tan; Chen Zhang; Zong-Wan Mao

doi:10.1039/C8CC00256H

Red fluorescent probes for real-time imaging of the cell cycle by dynamic monitoring of the nucleolus and chromosome†

Kang-Nan Wang,‡^a Xi-Juan Chao,‡^a Bing Liu,^a Dan-Jie Zhou,^a Liang He,^a Xiao-Hui Zheng,^b Qian Cao,^a Cai-Ping Tan,^a Chen Zhang^c and Zong-Wan Mao

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* Corresponding authors

^a MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, China
E-mail: cesmzw@mail.sysu.edu.cn

^b School of Pharmaceutical Sciences, Wenzhou Medical University, Zhejiang 325035, China

^c School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, China

^d College of Materials and Energy, South China Agricultural University, Guangzhou 510642, China

Abstract

Two cationic molecular rotors, 1 and 2, capable of real-time cell-cycle imaging by specifically dynamic monitoring of nucleolus and chromosome changes were developed. A further study shows that fluorescence enhancements in the nucleolus and chromosome are attributed to a combination effect of interaction with nucleic acid and high condensation of the nucleolus and chromosome.

Chemical Communications

Red fluorescent probes for real-time imaging of the cell cycle by dynamic monitoring of the nucleolus and chromosome†

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Red fluorescent probes for real-time imaging of the cell cycle by dynamic monitoring of the nucleolus and chromosome

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