Issue 51, 2018
From the journal:

Chemical Communications

Carboxylic and O-acetyl moieties are essential for the immunostimulatory activity of glucuronoxylomannan: a novel TLR4 specific immunostimulator from Auricularia auricula-judae†

Namal Perera, ORCID logo ‡abcd   Feng-Ling Yang, ORCID logo ‡a   Jeffy Chern, ORCID logo abe   Hsiao-Wen Chiu,fg   Chih-Yu Hsieh, ORCID logo g   Lan-Hui Li,h   Yan-Long Zhang,*i   Kuo-Feng Hua ORCID logo *gj  and  Shih-Hsiung Wu ORCID logo *abe  

* Corresponding authors

a Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan
E-mail: shwu@gate.sinica.edu.tw
Tel: +886-02-2785-5696

b Chemical Biology and Molecular Biophysics Program, Taiwan International Graduate Program, Academia Sinica, Taipei, Taiwan

c Department of Chemistry, National Tsing-Hua University, Hsinchu, Taiwan

d Faculty of Applied Sciences, Sabaragamuwa University of Sri Lanka, Sri Lanka

e Department of Chemistry and Institute of Biochemical Sciences, National Taiwan University, Taiwan

f Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan

g Department of Biotechnology and Animal Science, National Ilan University, Ilan, Taiwan
E-mail: kfhua@niu.edu.tw
Tel: +886-03-931-7626

h Department of Laboratory Medicine, Linsen, Chinese Medicine and Kunming Branch, Taipei City Hospital, Taipei, Taiwan

i Key Laboratory of Molecular Biology of Heilongjiang Province, College of Life Sciences, Heilongjiang University, Harbin 150080, China
E-mail: ylzhanghd@163.com

j Department of Pathology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan

Abstract

This study established the comprehensive repeating unit structure of immunologically active glucuronoxylomannan (AAPS) from wood ear mushroom, Auricularia auricula-judae. We identified Toll-like receptor 4 (TLR4) as a critical receptor involved in AAPS-induced macrophage activation to secrete pro-inflammatory cytokines. Molecular modeling data and chemical modifications of AAPS revealed that both carboxylic and acetyl moieties of AAPS are equally essential in TLR4 binding to exert in vitro immunostimulatory activity.

Graphical abstract: Carboxylic and O-acetyl moieties are essential for the immunostimulatory activity of glucuronoxylomannan: a novel TLR4 specific immunostimulator from Auricularia auricula-judae

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Article information

DOI
https://doi.org/10.1039/C7CC09927D
Article type
Communication
Submitted
29 Dec 2017
Accepted
16 May 2018
First published
18 May 2018

Chem. Commun., 2018,54, 6995-6998

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Carboxylic and O-acetyl moieties are essential for the immunostimulatory activity of glucuronoxylomannan: a novel TLR4 specific immunostimulator from Auricularia auricula-judae

N. Perera, F. Yang, J. Chern, H. Chiu, C. Hsieh, L. Li, Y. Zhang, K. Hua and S. Wu, Chem. Commun., 2018, 54, 6995 DOI: 10.1039/C7CC09927D

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