Base-promoted amide synthesis from aliphatic amines and ynones as acylation agents through C–C bond cleavage

Abstract

A new protocol for the synthesis of amides via base-promoted cleavage of the C(sp)–C(CO) bond of ynones with aliphatic primary and secondary amines under transition-metal-, ligand-, and oxidant-free conditions has been developed. This method exhibits a wide substrate scope, high functional group tolerance and exclusive chemoselectivity, as well as mild reaction conditions.