Issue 6, 2018
From the journal:

Chemical Communications

A highly fluorescent water soluble spirobifluorene dye with a large Stokes shift: synthesis, characterization and bio-applications†

Friederike Schlüter,a   Kristina Riehemann,b   Nermin Seda Kehr, ORCID logo b   Silvio Quici,c   Constantin G. Daniliuc ORCID logo a  and  Fabio Rizzo ORCID logo *ac  

* Corresponding authors

a Organisch-Chemisches Institut and CeNTech, Westfälische Wilhelms-Universität Münster, Corrensstrasse 40, 48149 Münster, Germany

b Physikalisches Institut and CeNTech, Westfälische Wilhelms-Universität Münster, Heisenbergstrasse 11, 48149 Münster, Germany

c Istituto di Scienze e Tecnologie Molecolari (ISTM) and INSTM, Consiglio Nazionale delle Ricerche (CNR), via Golgi 19, 20133 Milano, Italy
E-mail: fabio.rizzo@istm.cnr.it

Abstract

The first water-soluble spirobifluorene derivative has been synthesized, which exhibits high fluorescence quantum yield and a large Stokes shift (>100 nm). Proteins induce changes in the emission color, allowing to reach the nanomolar detection limit. Cellular uptake and cytotoxicity studies in living cells revealed its biocompatibility, indicating potential application for live cell imaging.

Graphical abstract: A highly fluorescent water soluble spirobifluorene dye with a large Stokes shift: synthesis, characterization and bio-applications

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Article information

DOI
https://doi.org/10.1039/C7CC08761F
Article type
Communication
Submitted
14 Nov 2017
Accepted
19 Dec 2017
First published
19 Dec 2017

Chem. Commun., 2018,54, 642-645

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A highly fluorescent water soluble spirobifluorene dye with a large Stokes shift: synthesis, characterization and bio-applications

F. Schlüter, K. Riehemann, N. S. Kehr, S. Quici, C. G. Daniliuc and F. Rizzo, Chem. Commun., 2018, 54, 642 DOI: 10.1039/C7CC08761F

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