Transition metal free regio-selective C–H hydroxylation of chromanones towards the synthesis of hydroxyl-chromanones using PhI(OAc)2 as the oxidant†
N.
Viswanadh, 
ab
Ganesh S.
Ghotekar,
ab
Aslam C.
Shaikh,
ab
M.
Karthikeyan
bc
and
M.
Muthukrishnan
*ab
ab
Ganesh S.
Ghotekar,
ab
Aslam C.
Shaikh,
ab
M.
Karthikeyan
bc
and
M.
Muthukrishnan
*ab
Abstract
The chromanone scaffold is considered as a privileged structure in drug discovery. Herein, we report a highly efficient PhI(OAc)2 mediated regioselective, direct C–H hydroxylation of chromanones. This method offers easy access to substituted 6-hydroxy chromanones in moderate to good isolated yields, thus paving the way for their pharmaceutical studies.
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