Issue 83, 2017
From the journal:

Chemical Communications

Highly sensitive detection of epidermal growth factor receptor in lung cancer cells by aptamer-based target-/probe-mediated cyclic signal amplification†

Dandan Zhang,‡a   Fei Ma,‡a   Qianyi Zhang‡b  and  Chun-yang Zhang ORCID logo *a  

* Corresponding authors

a College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Shandong Provincial Key Laboratory of Clean Production of Fine Chemicals, Shandong Normal University, Jinan 250014, China
E-mail: cyzhang@sdnu.edu.cn
Fax: +86 0531-82615258
Tel: +86 0531-86186033

b Nantou High School Shenzhen, Shenzhen, China

Abstract

We develop an antibody-free fluorescence method for the epidermal growth factor receptor (EGFR) assay using aptamer-based target-/probe-mediated cyclic signal amplification. The method is highly sensitive with a detection limit of 0.16 fM, and it can be applied to detect EGFR in lung cancer cells, holding great potential in clinical diagnosis.

Graphical abstract: Highly sensitive detection of epidermal growth factor receptor in lung cancer cells by aptamer-based target-/probe-mediated cyclic signal amplification

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Article information

DOI
https://doi.org/10.1039/C7CC06823A
Article type
Communication
Submitted
31 Aug 2017
Accepted
29 Sep 2017
First published
29 Sep 2017

Chem. Commun., 2017,53, 11496-11499

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Highly sensitive detection of epidermal growth factor receptor in lung cancer cells by aptamer-based target-/probe-mediated cyclic signal amplification

D. Zhang, F. Ma, Q. Zhang and C. Zhang, Chem. Commun., 2017, 53, 11496 DOI: 10.1039/C7CC06823A

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