Issue 96, 2017

A universal genotyping–microarray constructed by ligating a universal fluorescence-probe with SNP-encoded flaps cleaved from multiplex invasive reactions

Abstract

To achieve a microarray universal to any SNP, we proposed a new way to construct a genotyping–microarray by ligating a universal fluorescence-probe with SNP-encoded flaps cleaved from invasive reactions on a slide surface. Our proposed microarray is labor-saving and cost-saving in setting up a new experiment for genotyping multiple SNPs, which is related to personalized medicine.

Graphical abstract: A universal genotyping–microarray constructed by ligating a universal fluorescence-probe with SNP-encoded flaps cleaved from multiplex invasive reactions

Supplementary files

Article information

Article type
Communication
Submitted
24 Aug 2017
Accepted
10 Nov 2017
First published
10 Nov 2017

Chem. Commun., 2017,53, 12922-12925

A universal genotyping–microarray constructed by ligating a universal fluorescence-probe with SNP-encoded flaps cleaved from multiplex invasive reactions

Z. Chen, L. Miao, Y. Liu, T. Dong, X. Ma, X. Guan, G. Zhou and B. Zou, Chem. Commun., 2017, 53, 12922 DOI: 10.1039/C7CC06649J

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