The design of peptide-grafted graphene oxide targeting the actin cytoskeleton for efficient cancer therapy

Abstract

Graphene oxide (GO) nanosheets grafted with actin targeting and cell penetrating peptides were designed. The nanosheets were able to severely disrupt the organization of the tumor actin cytoskeleton, exhibiting excellent antitumor activity and high tumor specificity. This study implies the favorable potential of cancer therapies targeting the actin cytoskeleton.