Issue 75, 2017

Direct diversification of unmasked quinazolin-4(3H)-ones through orthogonal reactivity modulation

Abstract

Here we report a set of direct functionalization methods of unmasked 2-phenylquinazolin-4(3H)-ones, a privileged alkaloid core, without the installation/removal event of protecting groups or exogenous coordinating moieties. Divergent pathways were modulated with transition-metal catalysts by suppressing competitive reactivities, leading to N-arylation, annulative π-extension, or C–H fluorination.

Graphical abstract: Direct diversification of unmasked quinazolin-4(3H)-ones through orthogonal reactivity modulation

Supplementary files

Article information

Article type
Communication
Submitted
25 Jul 2017
Accepted
29 Aug 2017
First published
29 Aug 2017

Chem. Commun., 2017,53, 10394-10397

Direct diversification of unmasked quinazolin-4(3H)-ones through orthogonal reactivity modulation

J. B. Lee, M. E. Kang, J. Kim, C. Y. Lee, J. Kee, K. Myung, J. Park and S. Y. Hong, Chem. Commun., 2017, 53, 10394 DOI: 10.1039/C7CC05794F

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