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Issue 71, 2017
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Enhanced cancer therapy by the marriage of metabolic alteration and mitochondrial-targeted photodynamic therapy using cyclometalated Ir(III) complexes

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Abstract

Herein we present a series of DCA-Ir(III) co-drug complexes that preferentially accumulate in mitochondria and selectively cause cancer cell metabolic alterations and were found to act in synergy by sensitizing cancer cells for PDT to achieve cancer-specific enhanced two-photon PDT in the hypoxic environment of multicellular tumor spheroids.

Graphical abstract: Enhanced cancer therapy by the marriage of metabolic alteration and mitochondrial-targeted photodynamic therapy using cyclometalated Ir(iii) complexes

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Publication details

The article was received on 17 Jul 2017, accepted on 14 Aug 2017 and first published on 14 Aug 2017


Article type: Communication
DOI: 10.1039/C7CC05518H
Citation: Chem. Commun., 2017,53, 9878-9881
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    Enhanced cancer therapy by the marriage of metabolic alteration and mitochondrial-targeted photodynamic therapy using cyclometalated Ir(III) complexes

    J. Liu, C. Jin, B. Yuan, Y. Chen, X. Liu, L. Ji and H. Chao, Chem. Commun., 2017, 53, 9878
    DOI: 10.1039/C7CC05518H

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