Issue 71, 2017

Enhanced cancer therapy by the marriage of metabolic alteration and mitochondrial-targeted photodynamic therapy using cyclometalated Ir(iii) complexes

Abstract

Herein we present a series of DCA-Ir(III) co-drug complexes that preferentially accumulate in mitochondria and selectively cause cancer cell metabolic alterations and were found to act in synergy by sensitizing cancer cells for PDT to achieve cancer-specific enhanced two-photon PDT in the hypoxic environment of multicellular tumor spheroids.

Graphical abstract: Enhanced cancer therapy by the marriage of metabolic alteration and mitochondrial-targeted photodynamic therapy using cyclometalated Ir(iii) complexes

Supplementary files

Article information

Article type
Communication
Submitted
17 Jul 2017
Accepted
14 Aug 2017
First published
14 Aug 2017

Chem. Commun., 2017,53, 9878-9881

Enhanced cancer therapy by the marriage of metabolic alteration and mitochondrial-targeted photodynamic therapy using cyclometalated Ir(III) complexes

J. Liu, C. Jin, B. Yuan, Y. Chen, X. Liu, L. Ji and H. Chao, Chem. Commun., 2017, 53, 9878 DOI: 10.1039/C7CC05518H

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