Issue 66, 2017
From the journal:

Chemical Communications

A cascade enzymatic reaction activatable gemcitabine prodrug with an AIE-based intracellular light-up apoptotic probe for in situ self-therapeutic monitoring†

Haijie Han,a   Wenzhuo Teng,a   Tingting Chen,a   Jue Zhao,b   Qiao Jin, ORCID logo *ac   Zhihui Qina  and  Jian Ji ORCID logo *a  

* Corresponding authors

a MOE Key Laboratory of Macromolecule Synthesis and Functionalization of Ministry of Education, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, China
E-mail: jinqiao@zju.edu.cn, jijian@zju.edu.cn

b Department of Obstetrics, Zhejiang Provincial People's Hospital of Hangzhou Medical College, Hangzhou, China

c State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai, China

Abstract

A targeted cathepsin B-activatable gemcitabine prodrug with caspase-3 specific light-up tetraphenylene (TPE) as an apoptotic probe based on aggregation-induced emission (AIE) properties was designed for in situ self-therapeutic monitoring of pancreatic cancer cells.

Graphical abstract: A cascade enzymatic reaction activatable gemcitabine prodrug with an AIE-based intracellular light-up apoptotic probe for in situ self-therapeutic monitoring

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Article information

DOI
https://doi.org/10.1039/C7CC04872F
Article type
Communication
Submitted
23 Jun 2017
Accepted
25 Jul 2017
First published
25 Jul 2017

Chem. Commun., 2017,53, 9214-9217

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A cascade enzymatic reaction activatable gemcitabine prodrug with an AIE-based intracellular light-up apoptotic probe for in situ self-therapeutic monitoring

H. Han, W. Teng, T. Chen, J. Zhao, Q. Jin, Z. Qin and J. Ji, Chem. Commun., 2017, 53, 9214 DOI: 10.1039/C7CC04872F

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