Issue 62, 2017
From the journal:

Chemical Communications

Biomimetic iterative method for polyketide synthesis†

Kengo Akagawa*a  and  Kazuaki Kudo ORCID logo *a  

* Corresponding authors

a Institute of Industrial Science, The University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo 1538505, Japan
E-mail: akagawa@iis.u-tokyo.ac.jp, kkudo@iis.u-tokyo.ac.jp

Abstract

An iterative method for synthesizing polyketides was demonstrated, in which the chain elongation of a carboxylic acid was performed by decarboxylative dehydration condensation with a malonic acid half thioester. After transforming the resulting β-ketothioester into an appropriate form, the carboxylic acid functionality was regenerated for the next elongation step.

Graphical abstract: Biomimetic iterative method for polyketide synthesis

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Article information

DOI
https://doi.org/10.1039/C7CC04033D
Article type
Communication
Submitted
25 May 2017
Accepted
08 Jun 2017
First published
08 Jun 2017

Chem. Commun., 2017,53, 8645-8648

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Biomimetic iterative method for polyketide synthesis

K. Akagawa and K. Kudo, Chem. Commun., 2017, 53, 8645 DOI: 10.1039/C7CC04033D

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