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Issue 48, 2017
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A smart drug: a pH-responsive photothermal ablation agent for Golgi apparatus activated cancer therapy

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Abstract

We report a pH-responsive photothermal ablation agent (pH-PTT) based on cyanine dyes for photothermal therapy (PTT). The nanoparticles formed by BSA and pH-PTT preferentially accumulated in the Golgi apparatus of cancer cells compared to normal cells, and thus can be specifically activated by the acidic Golgi apparatus in cancer cells for effective PTT both ex vivo and in vivo.

Graphical abstract: A smart drug: a pH-responsive photothermal ablation agent for Golgi apparatus activated cancer therapy

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Publication details

The article was received on 25 Apr 2017, accepted on 22 May 2017 and first published on 22 May 2017


Article type: Communication
DOI: 10.1039/C7CC03168H
Citation: Chem. Commun., 2017,53, 6424-6427
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    A smart drug: a pH-responsive photothermal ablation agent for Golgi apparatus activated cancer therapy

    F. Xue, Y. Wen, P. Wei, Y. Gao, Z. Zhou, S. Xiao and T. Yi, Chem. Commun., 2017, 53, 6424
    DOI: 10.1039/C7CC03168H

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