Issue 58, 2017

Copper-catalyzed intermolecular asymmetric propargylic dearomatization of phenol derivatives

Abstract

A copper-catalyzed intermolecular asymmetric propargylic dearomatization of phenol derivatives has been realized. Under the catalysis of Cu(OTf)·1/2C6H6 decorated with a chiral tridentate ketimine P,N,N-ligand, the dearomatization reaction proceeded smoothly with excellent control of chemo-, regio-, and enantioselectivities, thus providing a variety of optically active cyclohexadienone derivatives with up to >99% ee.

Graphical abstract: Copper-catalyzed intermolecular asymmetric propargylic dearomatization of phenol derivatives

Supplementary files

Article information

Article type
Communication
Submitted
20 Apr 2017
Accepted
29 Jun 2017
First published
29 Jun 2017

Chem. Commun., 2017,53, 8192-8195

Copper-catalyzed intermolecular asymmetric propargylic dearomatization of phenol derivatives

L. Shao and X. Hu, Chem. Commun., 2017, 53, 8192 DOI: 10.1039/C7CC03034G

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