Issue 29, 2017
From the journal:

Chemical Communications

Integrating optical tweezers with up-converting luminescence: a non-amplification analytical platform for quantitative detection of microRNA-21 sequences†

Cheng-Yu Li,a   Di Cao,a   Chong-Yang Song,a   Chun-Miao Xu,a   Xu-Yan Ma,a   Zhi-Ling Zhang,a   Dai-Wen Panga  and  Hong-Wu Tang ORCID logo *a  

* Corresponding authors

a Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, P. R. China
E-mail: hwtang@whu.edu.cn

Abstract

We report a single-microsphere based imaging assay method by integrating up-converting luminescence with optical tweezers for detecting microRNA-21 sequences. This method achieves a competitive detection limit of 12 fM with good selectivity and no dedicated signal amplification designs.

Graphical abstract: Integrating optical tweezers with up-converting luminescence: a non-amplification analytical platform for quantitative detection of microRNA-21 sequences

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Article information

DOI
https://doi.org/10.1039/C7CC01133D
Article type
Communication
Submitted
13 Feb 2017
Accepted
14 Mar 2017
First published
14 Mar 2017

Chem. Commun., 2017,53, 4092-4095

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Integrating optical tweezers with up-converting luminescence: a non-amplification analytical platform for quantitative detection of microRNA-21 sequences

C. Li, D. Cao, C. Song, C. Xu, X. Ma, Z. Zhang, D. Pang and H. Tang, Chem. Commun., 2017, 53, 4092 DOI: 10.1039/C7CC01133D

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