Issue 40, 2017

Self-assembled DNA nanocentipedes as multivalent vehicles for enhanced delivery of CpG oligonucleotides

Abstract

We report self-assembled nanocentipedes as multivalent vehicles for the delivery of immunostimulatory CpG ODNs. The multivalent vehicles could be internalized by RAW264.7 cells and stimulate the secretion of large amounts of cytokines, successively inducing effective apoptosis of cancer cells.

Graphical abstract: Self-assembled DNA nanocentipedes as multivalent vehicles for enhanced delivery of CpG oligonucleotides

Supplementary files

Article information

Article type
Communication
Submitted
13 Feb 2017
Accepted
18 Apr 2017
First published
18 Apr 2017

Chem. Commun., 2017,53, 5565-5568

Self-assembled DNA nanocentipedes as multivalent vehicles for enhanced delivery of CpG oligonucleotides

W. Li, L. Luo, J. Huang, Q. Wang, J. Liu, X. Xiao, H. Fang, X. Yang and K. Wang, Chem. Commun., 2017, 53, 5565 DOI: 10.1039/C7CC01128H

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