Issue 32, 2017

A gold nanoparticle-mediated rapid in vitro assay of anti-aggregation reagents for amyloid β and its validation

Abstract

Herein, we report a rapid in vitro assay of amyloid β anti-aggregation reagents using gold nanoparticles as nucleation cores and optical reporters. Based on the colorimetric responses observed with the naked eye, effective anti-aggregation reagents were rapidly (<15 min) distinguished. For these reagents, conventional methods showed fewer amyloid β aggregates and an increased viability of neuroblastoma cells after treatment. We envision that our proposed method will facilitate the discovery of efficient drug components for the treatment of Alzheimer's disease.

Graphical abstract: A gold nanoparticle-mediated rapid in vitro assay of anti-aggregation reagents for amyloid β and its validation

Supplementary files

Article information

Article type
Communication
Submitted
14 Jan 2017
Accepted
16 Mar 2017
First published
16 Mar 2017

Chem. Commun., 2017,53, 4449-4452

A gold nanoparticle-mediated rapid in vitro assay of anti-aggregation reagents for amyloid β and its validation

H. Y. Kim, D. Lee, K. Ryu and I. Choi, Chem. Commun., 2017, 53, 4449 DOI: 10.1039/C7CC00358G

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