Issue 35, 2017
From the journal:

Chemical Communications

DNA-spheres decorated with magnetic nanocomposites based on terminal transfer reactions for versatile target detection and cellular targeted drug delivery†

Yingshu Guo,ab   Yujie Wang,ab   Shuang Li,ac   Li Niu, ORCID logo a   Di Weiad  and  Shusheng Zhang ORCID logo *a  

* Corresponding authors

a Shandong Province Key Laboratory of Detection Technology for Tumor Makers, School of Chemistry and Chemical Engineering, Linyi University, Linyi 276005, China
E-mail: shushzhang@126.com

b College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Shandong Normal University, Jinan 250014, China

c Shandong Provincial Key Laboratory of Life-Organic Analysis, College of Chemistry and Chemical Engineering, Qufu Normal University, Qufu, China

d Nokia Research Center, Broers Building, 21 J. J. Thomson Avenue, Cambridge, UK

Abstract

We present an elegant approach to make a magnetic nanoparticle (MNP) conjugated DNA-sphere (MNP/DNA-SP) which is integrated with disulfide (MNP/DS-SP) or an aptamer (MNP/sgc8-SP) for GSH detection, selective cancer cell recognition, effective drug delivery, and bioimaging.

Graphical abstract: DNA-spheres decorated with magnetic nanocomposites based on terminal transfer reactions for versatile target detection and cellular targeted drug delivery

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Article information

DOI
https://doi.org/10.1039/C7CC00310B
Article type
Communication
Submitted
13 Jan 2017
Accepted
30 Mar 2017
First published
06 Apr 2017

Chem. Commun., 2017,53, 4826-4829

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DNA-spheres decorated with magnetic nanocomposites based on terminal transfer reactions for versatile target detection and cellular targeted drug delivery

Y. Guo, Y. Wang, S. Li, L. Niu, D. Wei and S. Zhang, Chem. Commun., 2017, 53, 4826 DOI: 10.1039/C7CC00310B

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