Issue 36, 2017

O2-(6-Oxocyclohex-1-en-1-yl)methyl diazen-1-ium-1,2-diolates: a new class of nitric oxide donors activatable by GSH/GSTπ with both anti-proliferative and anti-metastatic activities against melanoma

Abstract

The new nitric oxide (NO) donor O2-(6-oxocyclohex-1-en-1-yl)methyl diazen-1-ium-1,2-diolate 3c could simultaneously liberate NO as well as an active 3-glutathionyl-2-exomethylene-cyclohexanone 2 in the presence of GSH/GSTπ; exhibit potent antiproliferative activity; repress migration, invasion, and lateral migration of metastatic B16–BL6 cells; and significantly decrease hetero-adhesion of B16–BL6 cells to human umbilical vein endothelial cells.

Graphical abstract: O 2-(6-Oxocyclohex-1-en-1-yl)methyl diazen-1-ium-1,2-diolates: a new class of nitric oxide donors activatable by GSH/GSTπ with both anti-proliferative and anti-metastatic activities against melanoma

Associated articles

Supplementary files

Article information

Article type
Communication
Submitted
10 Jan 2017
Accepted
07 Apr 2017
First published
12 Apr 2017

Chem. Commun., 2017,53, 5059-5062

O 2-(6-Oxocyclohex-1-en-1-yl)methyl diazen-1-ium-1,2-diolates: a new class of nitric oxide donors activatable by GSH/GSTπ with both anti-proliferative and anti-metastatic activities against melanoma

C. Bai, R. Xue, J. Wu, T. Lv, X. Luo, Y. Huang, Y. Gong, H. Zhang, Y. Zhang and Z. Huang, Chem. Commun., 2017, 53, 5059 DOI: 10.1039/C7CC00213K

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