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Issue 21, 2017
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Palladium-catalyzed cascade metallo-ene/Suzuki coupling reaction of allenamides

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Abstract

A new type of cascade metallo-ene/Suzuki coupling reaction of allenamides catalyzed by palladium is described. A variety of polyfunctionalized 2,3-dihydropyrrole derivatives, which are important structural motifs for bioactive molecules, were furnished with excellent yields. Two new Csp3–Csp2 bonds were constructed in one pot efficiently. The reductive elimination from π-allyl palladium complex presented excellent regioselectivity to the terminal C1 position. The unique terminal alkene was one of the most easily functionalized groups, providing these molecules with a potential transformation to much more complicated molecules.

Graphical abstract: Palladium-catalyzed cascade metallo-ene/Suzuki coupling reaction of allenamides

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Publication details

The article was received on 09 Jan 2017, accepted on 16 Feb 2017 and first published on 17 Feb 2017


Article type: Communication
DOI: 10.1039/C7CC00191F
Citation: Chem. Commun., 2017,53, 3138-3141
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    Palladium-catalyzed cascade metallo-ene/Suzuki coupling reaction of allenamides

    H. Liang, F. Yan, X. Dong, Q. Liu, X. Wei, S. Liu, Y. Dong and H. Liu, Chem. Commun., 2017, 53, 3138
    DOI: 10.1039/C7CC00191F

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