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Issue 19, 2017
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Efficient siRNA–peptide conjugation for specific targeted delivery into tumor cells

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Abstract

Despite the broad applicability of the Huisgen cycloaddition reaction, the click functionalization of RNAs with peptides still remains a challenge. Here we describe a straightforward method for the click functionalization of siRNAs with peptides of different sizes and complexities. Among them, a promising peptide carrier for the selective siRNA delivery into HER2+ breast cancer cell lines has been reported.

Graphical abstract: Efficient siRNA–peptide conjugation for specific targeted delivery into tumor cells

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Publication details

The article was received on 28 Dec 2016, accepted on 10 Feb 2017 and first published on 13 Feb 2017


Article type: Communication
DOI: 10.1039/C6CC10287E
Citation: Chem. Commun., 2017,53, 2870-2873
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    Efficient siRNA–peptide conjugation for specific targeted delivery into tumor cells

    A. Gandioso, A. Massaguer, N. Villegas, C. Salvans, D. Sánchez, I. Brun-Heath, V. Marchán, M. Orozco and M. Terrazas, Chem. Commun., 2017, 53, 2870
    DOI: 10.1039/C6CC10287E

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