αvβ3-Isoform specific erbium complexes highly specific for bladder cancer imaging and photodynamic therapy

Yan Zhou; Chi-Fai Chan; Daniel W. J. Kwong; Ga-Lai Law; Steven Cobb; Wai-Kwok Wong; Ka-Leung Wong

doi:10.1039/C6CC09246B

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α_vβ₃-Isoform specific erbium complexes highly specific for bladder cancer imaging and photodynamic therapy†

Yan Zhou,^a Chi-Fai Chan,^b Daniel W. J. Kwong,*^a Ga-Lai Law,*^b Steven Cobb,^c Wai-Kwok Wong*^a and Ka-Leung Wong

*^a

Author affiliations

* Corresponding authors

^a Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong Kong SAR, China
E-mail: wkwong@hkbu.edu.hk, klwong@hkbu.edu.hk

^b Department of Applied Biology and Chemical Technology, Hong Kong Polytechnic University, Hung Hum, Hong Kong SAR, China

^c Department of Chemistry, Durham University, Durham, UK

Abstract

We have synthesized a bifunctional erbium–porphyrin tumor imaging and PDT agent (Er–R₃) that is capable of killing bladder cancer cells via its selective binding to the integrin α_vβ₃ isoform overexpressed on the cell membrane.

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Article information

DOI: https://doi.org/10.1039/C6CC09246B
Article type: Communication
Submitted: 20 Nov 2016
Accepted: 05 Dec 2016
First published: 06 Dec 2016
This article is Open Access

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Chem. Commun., 2017,53, 557-560

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α_vβ₃-Isoform specific erbium complexes highly specific for bladder cancer imaging and photodynamic therapy

Y. Zhou, C. Chan, D. W. J. Kwong, G. Law, S. Cobb, W. Wong and K. Wong, Chem. Commun., 2017, 53, 557 DOI: 10.1039/C6CC09246B

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