Issue 12, 2017

Acetic acid as a catalyst for the N-acylation of amines using esters as the acyl source

Abstract

We report a cheap and simple method for the acetylation of a variety of amines using catalytic acetic acid and either ethyl acetate or butyl acetate as the acyl source. Catalyst loadings as low as 10 mol% afforded acetamide products in excellent yields at temperatures ranging from 80–120 °C. The methodology can also be successfully applied for the synthesis of a broad range of other amides, including the formation of formamides at 20 °C.

Graphical abstract: Acetic acid as a catalyst for the N-acylation of amines using esters as the acyl source

Supplementary files

Article information

Article type
Communication
Submitted
11 Nov 2016
Accepted
18 Nov 2016
First published
21 Nov 2016

Chem. Commun., 2017,53, 2020-2023

Acetic acid as a catalyst for the N-acylation of amines using esters as the acyl source

D. D. Sanz Sharley and J. M. J. Williams, Chem. Commun., 2017, 53, 2020 DOI: 10.1039/C6CC09023K

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements