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Issue 14, 2017
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A red-NIR fluorescent dye detecting nuclear DNA G-quadruplexes: in vitro analysis and cell imaging

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Abstract

Aggregation, red-NIR emission and light-up upon nucleic acid G-quadruplex binding have been investigated for a prototype core-extended naphthalene diimide, which is capable of fast cellular entry and nucleolar localization. Both high-level colocalization with an anti-G-quadruplex antibody and nucleolin displacement reveal that the compound targets and thus makes visible nuclear DNA G-quadruplexes.

Graphical abstract: A red-NIR fluorescent dye detecting nuclear DNA G-quadruplexes: in vitro analysis and cell imaging

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Publication details

The article was received on 21 Oct 2016, accepted on 23 Jan 2017 and first published on 23 Jan 2017


Article type: Communication
DOI: 10.1039/C6CC08492C
Citation: Chem. Commun., 2017,53, 2268-2271
  • Open access: Creative Commons BY license
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    A red-NIR fluorescent dye detecting nuclear DNA G-quadruplexes: in vitro analysis and cell imaging

    F. Doria, M. Nadai, M. Zuffo, R. Perrone, M. Freccero and S. N. Richter, Chem. Commun., 2017, 53, 2268
    DOI: 10.1039/C6CC08492C

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