Issue 2, 2017

Human carnitine biosynthesis proceeds via (2S,3S)-3-hydroxy-Nε-trimethyllysine

Abstract

N ε -Trimethyllysine hydroxylase (TMLH) catalyses the first step in mammalian biosynthesis of carnitine, which plays a crucial role in fatty acid metabolism. The stereochemistry of the 3-hydroxy-Nε-trimethyllysine product of TMLH has not been defined. We report enzymatic and asymmetric synthetic studies, which define the product of TMLH catalysis as (2S,3S)-3-hydroxy-Nε-trimethyllysine.

Graphical abstract: Human carnitine biosynthesis proceeds via (2S,3S)-3-hydroxy-Nε-trimethyllysine

Supplementary files

Article information

Article type
Communication
Submitted
18 Oct 2016
Accepted
29 Nov 2016
First published
29 Nov 2016
This article is Open Access
Creative Commons BY license

Chem. Commun., 2017,53, 440-442

Human carnitine biosynthesis proceeds via (2S,3S)-3-hydroxy-Nε-trimethyllysine

R. K. Leśniak, S. Markolovic, K. Tars and C. J. Schofield, Chem. Commun., 2017, 53, 440 DOI: 10.1039/C6CC08381A

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