Issue 89, 2016

Multifunctional single-layered vesicles derived from Cu(ii)-metal–organic-polyhedra

Abstract

Cu(II) metal–organic-polyhedra (MOP) derived from a tris-pyridyl ligand gave stable single-layered vesicles capable of encapsulating an anti-cancer drug (doxorubicin – DOX) and its pH responsive release. While encapsulation of DOX was further confirmed by MTT assay and cellular imaging, α-chymotrypsin inhibition assay corroborated well with the single crystal structures of the MOP. The MOP derived vesicles reported herein not only represent the rare examples of such hierarchical architectures derived from MOP but also provide the first example of multifunctional organic–inorganic synthetic bio-membranes.

Graphical abstract: Multifunctional single-layered vesicles derived from Cu(ii)-metal–organic-polyhedra

Supplementary files

Article information

Article type
Communication
Submitted
26 Sep 2016
Accepted
13 Oct 2016
First published
13 Oct 2016

Chem. Commun., 2016,52, 13124-13127

Multifunctional single-layered vesicles derived from Cu(II)-metal–organic-polyhedra

K. Sarkar, M. Paul and P. Dastidar, Chem. Commun., 2016, 52, 13124 DOI: 10.1039/C6CC07804D

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